Opportunities for improving the performance of LCV micelle gel dosimeters: II. Recipe optimization

摘要

Designed experiments and empirical models are used to optimize a Leuco Crystal Violet (LCV) micelle gel recipe to improve dose sensitivity and initial colour. The optimized recipe contains 0.75 mM LCV, 17.0 mM Cetyl Trimethyl Ammonium Bromide (CTAB), 120 mM 2,2,2-trichloroethanol (TCE), 25.0 mM tri-chloro acetic acid (TCAA), 4 wt% gelatin and ～96 wt% water. Dose sensitivity of the optimized gel is 1.5 times higher than Jordan's standard LCV gel. Spatial integrity of the 3D dose distribution information in 1L jar phantoms made using this recipe is maintained for more than two weeks.