Preparation of Drug-loaded Porous Poly-L-lactide Microspheres Using Compressed CO2 Antisolvent Process

摘要

By virtue of excellent aerodynamic properties,porous microspheres (PMs) have been considered as an effective inhalable drug carrier.Compared with traditional methods,supercritical CO2 fluid technologies have shown great advantages in preparing PMs[1].However,the size and porosity of the resulting PMs usually could not simultaneously meet the requirements of pulmonary drug delivery.