A Study of the Best Extraction Technology of Nasal Mucosa Dosing Bromo Gels

摘要

In the paper, the best extraction technology of nasal mucosa dosing bromo gels is preferably selected. Orthogonal test is applied to screen the best technological condition for extracting nasal mucosa dosing bromo gels with content of ferulic acid and gastrodin as the indexes; it is figured out that the best technological condition is ethanol; the optimal technology is stable and feasible and can raise content of ferulic acid remarkably. Nasal mucosa dosing bromo gels belongs to a kind of pure Chinese materia medica preparation and is mainly used to cure headache. Hemlock parsley prescription is created by famous medical scientist Liu Wansu in Jin and Yuan Dynasties; in the prescription, hemlock parsley can invigorate the circulation of blood and promote the circulation of the whole body; gastrodia elata can relieve dizziness and pain; both have good therapeutic effects to blood stasis, retardation and migraine. We can say it is simple with excellent curative effect. The prescription consists of hemlock parsley and gastrodia elata[2] and has good curative effect to headache with faint toxic and side effects via several years of clinical trial; besides, anaphylaxis is rarely seen to patients. Its effective elements can be extracted by water extraction according to physical and chemical properties of medicines in the prescription. It is tested in experiments that the index element of ferulic acid is lower than that of ethanol purely acquired by water extraction. In plenty of document retrievals and patent searches, technological conditions for extracting ferulic acid, volume fraction, extraction times and extraction time of ethanol are not taken as investigation conditions. It has been proved through deeply researches and repeated experiments of physical and chemical properties and pharmacological effects of medicines in the prescription that extract times remarkably influence extraction efficiency. Above all, investigation factors are conformed; orthogonal test is conducted and technological conditions for extracting ferulic acid are screened.