Polymer-tethered pH-sensitive Magnetic Nanoparticles for Targeted Delivery of Anti-cancer Drug

摘要

Efficient delivery of drug to tumor cells is one of the crucial issues in cancer therapy. This letter addresses for the first time that poly(acrylic acid) (PAA), a pH-sensitive polymer, is tethered to the surface of the nanoparticles by chemical grafting. The release rates of doxorubicin (DOX) are subsequently studied in vitro. The results reveal that DOX can be released preferentially at the desired lysosomal pH, and show that the anti-cancer drug carrier can be applied to the biomedical applications.