To explore the expression changes of trefoil factor 2 ( TFF2 ) and trefoil factor3 (TFF3) gene in submandibular glands during the self healing of experimental gastric ulcer in rats for revealing the relationship between them. The expression of TFF2, TFF3 peptide and genes were detected by immunohistochemistry and RT-PCR methods respectively in gastric ulcer group, saline control group and normal group. The results were as follows: ( 1 ) TFF2 peptide showed strong expression in dark cells with few granules or in those cells without granules, but weakly positive or negative in cells with many granules. The expression was stronger in male rats than that in female rats. The optical density values (OD) values obviously increased on the day 1 after gastric ulcer (P
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