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LASER INDUCED HYPERTHERMIA OF SUPERFICIAL TUMORS: A TRANSIENT THERMAL MODEL FOR INDIRECT HEATING STRATEGY

机译:激光诱导浅表肿瘤的热疗:间接加热策略的瞬态热模型

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An indirect heating strategy based on laser irradiation of surrounding tissues as an alternative to a direct irradiation of superficial tumors is presented in this paper. The computational analysis is based on two-dimensional axisymmetric models for both radiative transfer and transient heat transfer in a human body. Coupled transient energy equations and kinetic equations for composite human tissue take into account the metabolic heat generation and heat conduction, blood perfusion through capillaries, the volumetric heat transfer between arterial blood and ambient tissue, the thermal conversions in blood and tumor tissue, the periodic laser heating, and also heat transfer between the human body and ambient medium. An example problem for a superficial human cancer has been solved numerically to illustrate the relative role of the problem parameters on the transient temperature field and degree of thermal conversions in human tissues during hyperthermia treatment. In particular, the effect of embedded gold nanoshells which strongly absorb the laser radiation is analyzed. It is shown that required parameters of tumor hyperthermia can be also reached without gold nanoshells.
机译:本文介绍了基于周围组织的激光照射的间接加热策略作为浅表肿瘤直接照射的浅色肿瘤。计算分析基于二维轴对称模型,用于在人体中辐射转移和瞬态传热。耦合瞬态能量方程和复合人类组织的动力学方程考虑到代谢发热和热传导,血液灌注通过毛细血管,动脉血和环境组织之间的体积传热,血液和肿瘤组织的热转换,周期性激光加热,以及人体和环境介质之间的传热。在数值上已经解决了浅表患者癌症的示例问题,以说明问题参数对高温治疗期间人组织中的瞬态温度场和热转化程度的相对作用。特别地,分析了强烈吸收激光辐射的嵌入金纳米孔的效果。结果表明,也可以达到肿瘤热疗的所需参数,而无需金纳米。

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