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Nanodiamond microelectrode array with mesa structure fabricated for bio-analytical applications

机译:纳米二胺微电极阵列,具有用于生物分析应用的MESA结构

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Ultra-microelectrode arrays (UMEAs) are widely used because of advantages such as low capacitance and low iR losses, which provides a high signal/noise ratio and allows use in highly resistive media. They also can be used in applications requiring high temporal and spatial resolution. Hemispherical diffusion enhances the flux density at the microelectrode surface to provide greater sensitivity than macroelectrodes. Catecholamine neurotransmitters, such as dopamine, play important roles in the mammalian central nervous system and require constant monitoring and measurement. A nitrogen incorporated nanodiamond UMEA was fabricated using silicon microfabrication technology and microwave PECVD process by using a 'top-down' approach. This process allows greater control over the UMEA dimensions and nanodiamond microstructure. The array consists of 2500 UME 'mesas' projecting above the surrounding insulating matrix of spin-on-dielectric. Cyclic voltammetry was used to characterize the UMEA for detection of dopamine.
机译:超微微电极阵列(UMEAS)是广泛使用的,因为诸如低电容和低IR损耗的优点,其提供高信号/噪声比,并允许在高电阻介质中使用。它们还可用于需要高时和空间分辨率的应用中。半球形扩散增强了微电极表面的磁通密度,以提供比宏观电极更大的灵敏度。儿茶酚胺神经递质,如多巴胺,在哺乳动物中枢神经系统中起重要作用,需要持续的监测和测量。使用“自上而下”方法,使用硅微制造技术和微波PECVD工艺制造氮掺入的纳米金刚胺。该过程允许更好地控制UMEA尺寸和纳米二胺微观结构。该阵列由旋转介质的周围绝缘矩阵上方的2500 Ume'Mesas'突出。循环伏安法用于表征UMEA以检测多巴胺。

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