The dynamical effects of initial orientation and deformation of projectile and target on the ~(238)u+~(238)U reaction have been studied by using the improved quantum molecular dynamics model. The production probability of superheavy fragments(SHF) with Z> 110 at incident energies 7-12A MeV are investigated for different orientations and deformations of two colliding nuclei. The inclusion ofβ34 deformation in prolate uranium seems to enhance the production probability of SHF in the side-side case as the more stable structure of initial uranium effectively reduces the excitation energy of the composite system. It is suggested that the optimal initial condition for production of SHF in ~(238)U+~(238)U could be the side-side orientation and prolate deformation with a small β4 deformation in the ground state of uranium.
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