Redox PotentialSensor Arrayby Extended-Gate FET with Ferrocenyl-Alkanethiol Modified Gold Electrode

摘要

We developed a 32×32 array chip of extended-gate FET-based redox potential sensor with 11-ferrocenyl-1-undecanethiol (11-FUT) modified gold electrode. The sensor array detected the redox reaction of hexacyanoferrate (II) and hexacyanoferrate (III) as a change in the electric potential of the 11-FUT modified electrode in accordance with the Nernstian response at a slope of 57.9 mV/decade at 25 °C with a dynamic range of more than five orders of magnitude. The stability of the potential was within 0.5 mV/h. Of all 32×32 sensor cells, each potential of 80% and each difference of 92% were within ± 5 mV and ± 1 mV from median, respectively. The 2-dimensional and real time visualization were enabled by imaging of sensor array. Using an enzyme-catalyzed redox reaction, this FET-based sensor array successfully detected a glucose level from 25 to 200 mg/dL.