SENSITIVE DEPENDENCE ON THE THRESHOLD FOR TAF SIGNALING IN SOLID TUMORS

摘要

A model of tumor vascularization introduced by Stamper et al~8 is further investigated to study the role of a threshold for TAF production by the tumor. This threshold is shown to have three distinct regions which distinguish tumor growth patterns, including a critical region in which the tumor is particularly sensitive to the threshold value. The presence of these regions has implications for tumor classification and potential therapeutic targets.