Docking Interaction Study on Commercial Tyrosinase Inhibitors and Tyrosinase

摘要

@@ Tyrosinase is the key enzyme in melanin biosynthesis, which affects developmental and defensive functions of insects. The current commercial tyrosinase inhibitors (such as kojic acid, arbutin and azelaic acid) have no common frameworks. Understanding the interaction mode between these inhibitors and tyrosinase is very useful to screen the novel inhibitors. So, in the present study, the molecular docking was employed to analyze the interaction features using the Surflex-dock method in SYBYL7. 3 software.