Risk Factors Analysis based on the Cervical Cancer Screening Program performed on 728,704 women in Beijing, 2009

摘要

Objective: To detect cervical intra-epithelium neoplasm and cervical cancer among women in Beijing and to study risk factors of cervical intraepithelium neoplasm Ⅱ (CIN2), cervical intraepithelium neoplasm Ⅲ (CIN3) and cervical cancer. Methods: The cervical cancer screening program was performed on 728,704 women aged 25 to 65 years by pap smear, Thinprep cytologic test (TCT) and gynecological examination. Multilevel logistic regression was conducted to study risk factors of cervical intra-epithelium neoplasm Ⅱ (CIN2) and cervical intra-epithelium neoplasm Ⅲ (CIN3). A case-control study was performed to evaluate risk factors of cervical cancer. Results: The prevalence of cervical intra-epithelium neoplasm and cervical cancer is 132.84 per 100,000. The prevalence of cervical intra-epithelium neoplasm Ⅱ (CIN2) and cervical intra-epithelium neoplasm Ⅲ (CIN3) is 70.40 per 100,000. The prevalence of cervical cancer is 12.21 per 100,000. The risk factors of cervical intra-epithelium neoplasm Ⅱ (CIN2) and cervical intra-epithelium neoplasm Ⅲ (CIN3) include whether vaginal secretion is bloody or not (OR=2.77, 95% CI: 1.01-7.61), cervical ectropion (OR=2.10, 95% CI: 1.61-2.73), cervical contact bleeding (OR=1.43, 95% CI: 1.07-1.92), old cervical laceration (OR=2.49, 95% CI: 1.17-5.30), trichomonas vaginitis (OR=2.21, 95% CI: 1.12-4.39), other vaginitis (OR=2.61, 95% CI: 2.02-3.38), condyloma (OR=34.03, 95% CI: 10.60-109.28) and age group of 3645 compared with the age group of 56-65 (OR=1.86, 95% CI: 1.36-2.55). The risk factors of cervical cancer include cervical ectropion (OR=3.89, 95% CI: 1.4310.57) and cervical contact bleeding (OR=8.04, 95% CI: 2.68-24.10). Conclusion: The main risk factors of cervical intraepithelium neoplasm Ⅱ (CIN2) and cervical intraepithelium neoplasm Ⅲ (CIN3) are whether vaginal secretion is bloody or not, cervical ectropion, cervical contact bleeding, old cervical laceration, trichomonas vaginitis, other vaginitis, condyloma and age. The main risk factors of cervical cancer are cervical ectropion and cervical contact bleeding.