Optimization of SERRS signals based on Gold Nanoparticles synthesized by laser ablation and a new functionalized Nile Blue dye

摘要

Surface Enhanced Resonant Raman Scattering is a spectroscopic tool alternative to fluorescence in bio-sensing devices because of its high response in particular in multiplexing experiments. We use Gold Nanoparticles (AuNPs), synthetized with Laser Ablation Synthesis in Solution (LaSiS), to obtain aqueous colloidal solutions without any surfactant and therefore characterized by high reactivity. To optimize the SERS signals we aggregate the AuNPs to obtain a large number of hot spot, where the local electric field is strongly enhanced.