On the Determination of Content of 10 - DABIII in Enshi's Taxus Chinensis Var Mairei

摘要

Chemical semi-synthetic method for efficient low toxicity of paclitaxel analogues is the hot issue quite a long time in the present and the future of chemical, biological medicine and related interdisciplinary researches. 10-DABIII is the main precursor semi-synthetic raw materials. Taking Enshi's perennial natural taxus chinensis and taxus chinensis leaves of artificial cultivation as raw material to study the effect of different drying methods and extraction methods on the contents of 10-DABIII. Experimental results show that the 10-DABIII in the natural taxus chinensis is higher than that of artificially cultivated taxus chinensis; different drying methods affect the amount of 10-DABIII, that is, by contrast, drying processing method in 50 °C low temperature is superior to drying in the shade of the nature, and microwave extraction is more efficient than conventional solvent one. Knowing the content of 10-DABIII in Enshi's taxus chinensis can provide the necessary experimental data for rational utilization of taxus chinensis medicinal material resources, to promote Enshi's local economic development.