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Mapping the Histology of the Human Tympanic Membrane by Spatial Domain Optical Coherence Tomography

机译:通过空间域光学相干断层扫描来映射人鼓膜膜的组织学

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The tympanic membrane is one of the major structures of the ear that aids in the hearing process, giving humans one of the five major senses. It is hypothesized that sound induced displacements of the membrane, which allow humans to hear, are directly related to the membrane's medial layer which is comprised of a network of collagen fibers. Limitations in available medical imaging techniques have thus far inhibited the further study of these fibers. In this paper we detail an imaging system that we developed with the capability to quantitatively and noninvasively image the internal structures of biological tissues in vitro through spatial domain optical coherence tomography (OCT). By utilizing spatial OCT, we can correlate the characteristics of internal collagen fibers to sound induced displacements in the tympanic membrane. This will eventually lead to improved modeling of the middle-ear and a better understanding of hearing mechanics.
机译:鼓膜是耳朵的主要结构之一,有助于听力过程,使人类成为五个主要感官之一。假设允许人类听到的膜的声音诱导的位移与膜的内侧层直接相关,该内侧层由胶原纤维网络组成。因此,可用的医学成像技术的局限性抑制了对这些纤维的进一步研究。在本文中,我们详细介绍了一种成像系统,我们通过空间域光学相干断层扫描(OCT)来定量和非侵入地图像在体外进行定量和非侵入地图像的内部结构。通过利用空间OCT,我们可以将内胶原纤维的特性与鼓膜膜中的声音诱导的位移相关联。这最终将导致中耳的改进建模,并更好地了解听力机制。

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