Synthesis and anti-bacteria activity of a Gemini cationic surfactant

摘要

As quaternary ammonium cationic surfactants are widely employed in pharmaceutical and cosmetic industries and in many applications, to develop new functional quaternary ammonium cationic surfactant, a new cationic surfactant was synthesized and characterized. The critical micelle concentration (CMC) and foamability and foam stability were evaluated, and the results showed that it reaches to 32.0 mN/m at the concentration of 1×10~(-3) mol/L, the minimum surface tension was around 29.8 mN/m beyond 1×10~(-2) mol/L. This compound was evaluated for their in vitro antimicrobial activity against six bacteria (S. aureus, S. epidermidis, M. luteus, E. coli, K. pneumoniae, A. fumigatus). It some anti-inflammatory activity against the tested bacteria and the inhibition is depending on the concentration.