Molecularly Imprinted Polymer Microspheres Prepared by Precipitation Polymerization for Atenolol Recognition

摘要

Molecularly imprinted polymer microspheres for selective binding and recognition of atenolol were prepared by means of precipitation polymerization method using methacylic acid as functional monomer and trimethylolpropane trimethacrylate as cross-linker in the presence of atenolol as template molecule in acetonitrile solution. Computer simulation was employed to demonstrate the mechanism of the interaction between methacylic acid and atenolol. The scanning electron microscopy exhibited that the polymers were uniform spheres with the diameter of about 0.6um. The adsorption properties of atenolol for imprinted microspheres were evaluated by equilibrium rebinding experiments.