Research of effects of aloe polysaccharides on changes in cytokines during myocardial ischemia reperfusion injury in rabbits

摘要

To investigate the effect of AP on tumor necrosis factor, interleukin -6 and Interleukin -8 during myocardial ischemia-reperfusion injury. Forty New Zealand rabbits were randomly divided into five groups(n = 8) , sham group(group A) , myocardial ischemia reperfusion group(group B) . Complex Danshen tablets group(group C) , AP low dose group(group D) AP high dose group(group E). The concentrations of serum TNF-a, IL-6, IL-8 were detected. The result shows that, the level of TNF-a increased obviously in 30 minutes after myocardial ischemia and after reperfusion in groups C, D, E. but less than that in group B (P<0.05 or P<0.01); the level of IL-6 and IL-8 increased obviously after reperfusion in groups C, D, E , but less than that in group B (P < 0.05 ). Experimental studies may arrive at the conclusion that AP can inhibit the production of serum TNF-a, IL-6, and IL-8 , which can protect heart tissue during myocardial ischemia and reperfusion.