CLINICAL USE OF PLATELET RICH PLASMA IN PROBLEMATIC WOUNDS

摘要

While platelet rich plasma (PRP) was initially described in the 1970s, the clinical use of PRP in a peer reviewed literature in human medicine was first described in 1990 with platelet gel (PG) application utilized as an alternative to fibrin as a sealant during cardiovascular surgery. Clinical use on animals was documented in 2001 when the effet of a PG on bone formation of calvarial defects in rabbits was evaluated. Since then, PRP has been described for uses including non-healing wounds, diabeticfoot ulcers, chronic and acute tendonopathy, and closure following medial sternotomy. The primary clinical application of PG is to promote wound healing by increasing the local concentration of growth factors involved in the migration, proliferation andmaturation at the site of injury. Additionally, PG has been shown to exert anti-infective properties the etiology of which remains theoretical.