Multimodal Simulation of the Phage-λ Decision Cycle

摘要

A model of the lysis-lysogeny decision cycle of the Phage-λ virus has been re-implemented using standard engineering tools. The model is constructed using the biological knowledge of the protein signalling networks within the virus obtained from previous systems biology based work. It explores how emergent effects from multiple individual protein interactions produce the observed lysis-lysogeny behaviour. The software tools used (LabVIEW and MATLAB) were chosen as they do not require specialised biochemical knowledge, and have a wide engineering user base. This modelling performed to provide groundwork for Project Fallot at Loughborough University, which is producing a multiscale model of congenital heart disease development. Part of this research requires a model of Delta-Notch protein signalling, and comment is made on the implemented modelling technique's application to this cellular signalling pathway.