Characteristic conformational patterns of the Trp- and Arg-rich antimicrobial peptides

摘要

In this study, molecular dynamics simulations were performed on certain stereoi-someric forms of indolicidin and tritrpticin, in order to identify their characteristic conformational patterns. Based on the results, it could be concluded that the stere-oisomers of both Trp- and Arg-rich antimicrobial peptides showed typical patterns with regard to their secondary structural elements, as well as to their intramolecular interactions.