Sustained release liposome for pulmonary drug delivery

摘要

Purpose: The objective of this study was to establish drug loaded liposome with sustained release property for pulmonary application. Methods: The drug for lung disease therapy (drug A) loaded liposome was prepared by ammonium ion gradient method. Physicochemical characteristics such as particle size and drug encapsulation efficiency were evaluated. The drug release profiles of the different formulation of liposomes were analyzed by dialysis method. Results: Loading of drug A into liposome of around 60% entrapment efficiency was achieved by an ammonium ion gradient method. Entrapment efficiency could be controlled by changing the lipid properties and incubation temperature on processing. The release profile of drug A from liposome prepared by this method exhibited the sustained release. The drug release pattern depended on the phase transition temperature of lipid and ammonium salt using preparation process of liposome. Surface modification with hydrophilic polymer prolonged the drugs releasing from liposome. Conclusion: These results indicate that drug A loaded liposome prepared by ammonium ion gradient method have a high potential for pulmonary delivery with sustained release property.