A Novel Human Cytotoxic Cell Activation Factor with anti-Cancer Activity

摘要

We report the isolation of a novel human Cytotoxic Cell Activation Factor (CCAcF). We found that the cDNA of this protein is expressed mainly in the human pancreas and kidney and partially in the placenta. CCAcF is also expressed in monocytes and CD8 cells, but only when these cells are activated, not when they are in a resting state, while rested CD19 lymphocytes do express CCAcF. We showed that application of CCAcF to acute myeloid leukemia cells (U937 premeyloid cells), human melanoma (CAG), human pancreatic cancer cells (Panc1) and human prostate cancer cells (PC3) inhibits the proliferation in vitro. In contrast, CCAcF doesn't affect healthy cells. Treatment of mice with induced pancreatic cancer eradicated the tumor in 60% of the treated mice, even when treatment began in a late stage of cancer development.