The Prognosis Value of the hTERT Gene in the Evaluation of Pulmonary Metastasized Testicular Carcinomas on a Reduced Number of Cases

摘要

Pulmonary metastases are frequently met in testicular cancers. Determining the pulmonary relapse model, studying prognosis factors for defining risk groups and applying different therapeutic strategies with the evaluation of survival represent the study's main objectives. We've taken into our study patients diagnosed with testicular cancer all presenting pulmonary, pleural or mediastinal metastases. We evaluated the risk factors correlated with survival: the average age is 29.63 (p=0.613), place of origin (p=0.895), histology (p=0.078 >0, 05); tumor markers for our batch: Beta HCG, AFP (alpha-fetoprotein); LDH does not influence survival (p=0.786), (p= 0.345) respectively (p= 0.153). Types of pulmonary metastases: (p=0.08 >0, 05). The presence of other metastases: does not influence survival (p= 0.439). The number of metastatic locations (p= 0.465 > >0, 05). Risk groups (p= 0.0254 <0, 0). Because the risk factors usually available are not sufficient to identify the subgroups of patients with an unfavorable prognosis, we tried to evaluate new genetic markers which could prove their prognosis value. The expression of the hTERT gene and the increase of telomerase's activity strongly correlate with the emphasis of certain malignant tumors as well as with the presence of metastases.