Hydroxyapatite Coating on Cp-Ti Implants by Biomimetic Method

摘要

Hydroxyapatite (HA) is the main inorganic component in the human hard tissues, such as bones and teeth. The use of HA in load-bearing orthopedic applications has been extensively studied to achieve a biocompatible coating layer on implant metals. Commercial pure titanium (cp-Ti) is the most commonly used metallic material in the manufacture of orthopedic implants. Uncoated metal surfaces generally show numerous toxic effects to the surrounding tissues. However, coating of the metallic surfaces before implantation may prevent the interference of implant surfaces in biological media and also could accelerate the new bone formation. The present study focused on the coating of HA on cp-Ti implants, using novel biomimetic sol-gel method. The surfaces of cp-titanium substrates were coated with novel biomimetic sol gel (BSG) method under biological conditions (37°C and pH= 7.4). A bone-like apatite with a nanosized and pure HA structure was formed on the substrates under atmospheric pressure. The pre-coating results indicate that the novel biomimetic sol gel method is definitely a promising coating route in case that optimum coating parameters are established in detail.