Synthetic Helical Polymers and Diblock Copolymers: Building Blocks for Biocompatible/Biofunctional Helical Superstructures

摘要

Bottom-up design of materials via self-assembly with appropriate building blocks offers the possibility of developing innovative three-dimensional all synthetic materials with new functionalities. Helical optically active poly(3-methyl-4-vinylpyridine)/(R) and (S) mandelic acid and helical optically active poly(3-methyl-4-vinylpyridine) (P3M4VP)/D- and L- amino acid complexes have been prepared. A diblock copolymer of helical poly[(3-methyl-4-vinylprydine)/mandelic acid complex]-block-poly(styrene) has been processed into smectic layer-like helical-bundle structures on silicon wafer. Additionally, optically active helical poly(2-methoxystyrene) (P2PMS) has been synthesized and the surfaces of the chiral helical P2MS have been shown to be effective as supports for mouse and human osteoblast cells. The cell attachment and growth data demonstrate that the chiral P2MS surfaces were better supports compared to achiral P2MS surfaces.