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Experimental Study Regarding the Comparative Behavior of Three Osteoconductive Bone Graft Substitutes

机译:三骨导电骨移植替代品比较行为的实验研究

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The aim of this study is to reveal the integration, bone reaction and and extent of osseous healing for 3 types of osteoconductive graft substitutes used on experimental bone defects performed in rabbit femurs. The authors have performed an in vivo study on 2 groups of 6 rabbits with induced bone defect in distal femoral epiphysis. There have been used 3 types of BGS: Eurocer 400 (FH Orthopedics) – a biphasic BGS (55% hydroxyapatite and 45% tri-calcium phosphate), as granules, Euro bone (FH Orthopedics) an injectable BGS (55% bi-calcium phosphate and 45% tri-calcium phosphate), Osteoset (Wright) – calcium sulphate BGS as pellets. The bone defect in the first group was filled with Eurocer400 on the right femur and with Osteoset in the left femur. In the second group, the bone defect on the right femur was filled with Eurobone and the left femur with Eurocer400. The rabbits were sacrificed at 2 months after bone graft implantation and radio logic and histological examination were performed. Periimplant bone fragments were cut, processed and decalcified. Serial sections were stained by hematoxylin-eosin and van Gieson tehcnique. X-ray examination showed a good Osseo integration for Eurocer and Eurobone. The 2 main disadvantages of Osteoset pellets are the poor biological integration and fast resorbtion. However, we have remarked a poor density of the material at 2 months post-implantation, with important fragmentation at the implantation place. Eurocer and Eurobone showed a good Osseo integration with new bone formation. Osteoset pellets must be reserved to cavity defects with small contact area with fluid, thus avoiding the BGS to dissolve too fast. However, calcium sulphate Osteoset can be used as carrier for antibiotics, as well as of bone inductive molecules.
机译:本研究的目的是揭示用于3种类型的骨导电接枝替代品的整合,骨反应和和骨愈合的程度,用于兔股骨中的实验骨缺陷。作者对2组的6只兔患者进行了体内研究,其诱导骨缺损在远端股骨骨骺。已使用3种BGS:EUROCER 400(FH骨科) - 一种双相BGS(55%羟基磷灰石和45%三钙磷酸钙),作为颗粒,欧元骨(FH骨科)注射BGS(55%双钙磷酸盐和45%三钙磷酸钙),骨质体(赖特) - 硫酸钙BGS作为颗粒。第一组的骨缺损在右股骨上填充Eurocer400,左侧股骨中的骨质体。在第二组中,右股骨上的骨缺陷充满了Euroocer400的Eurobone和左股骨。在骨移植物注入和无线电逻辑和组织学检查后2个月处死兔子。切割,加工和脱钙化骨片段。连续部分染色苏木精 - 曙红和van Gieson Tehcnique。 X射线检查显示了Eurocer和Eurobone的良好osseo集成。骨质颗粒的2个主要缺点是生物整合差和快速resorbet。然而,我们在植入后2个月内阐述了物质密度较差,在植入地点具有重要的碎片。 EUROCER和EUROBONE展示了与新骨骼形成的良好综合。骨质体颗粒必须保留在具有流体的小接触面积的腔缺陷,从而避免BGS溶解太快。然而,硫酸钙骨质可以用作抗生素以及骨感应分子的载体。

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