Electrochemical detection of DNA hybridization based on bismuth oxide nanoparticles/chitosan-modified electrodes with methylene blue as an electrochemical indicator

摘要

The detection of DNA hybridization is of central importance to the diagnostic and treatment of genetic diseases, for the detection of infectious agents, and for reliable forensic analysis [1]. The technique for the detection of DNA hybridization has attracted many attentions. Many methods for detecting hybridization have been developed, including electrochemical, optical, microgravimetric methods and surface plasma resonance. As compared with other detection techniques, the main advantages of electrochemical techniques are their low cost, small size, and convenience for integration and microminaturizaion. Hence, DNA electrochemical biosensors have been rapidly developed recently [2–7].