Nano-Sized Carriers for Carbon Monoxide Releasing Molecules

摘要

Nanoparticles (NPs) can not only act as scaffolds, but also can be used to trigger carbon monoxide (CO) release. The very elegant light-induced CO release can so far only be used in treatment of surface tissues as the light used does not penetrate deeply into tissues. Here we report on our on-going work to modify the CO release characteristics by incorporation into nano-scale composites. Different biocompatible nanoparticles were decorated by CO-releasing molecules (CORMs). For effcient decoration we developed a L-DOPA (Levodopa, L-3,4-dihydroxyphenylalanine) derived CORM-3 analog. The CORM-functionalized NPs show temperature and pH-dependent CO release.