SeizAlert: Seizure Forewarning via Scalp EEG

摘要

SeizAlert is a low-cost, wearable device to forewarn of an impending epileptic seizure. The technology, covered by eight patents, presently uses brain-wave data from four scalp electrodes at the front of the scalp, removes eye-blink (and other muscular) artifacts that would otherwise confound the analysis, converts the artifact-filtered data into a statistical distribution function (DF), and compares the DF for the baseline period with subsequent DFs via statistical measures of dissimilarity. Several hours forewarning of an impending event is provided by multiple, successive occurrences of the dissimilarity measures above a threshold. The resultant total true rate is 93% with a false positive rate that is more than an order of magnitude below the clinically acceptable value. R&D Magazine awarded its prestigious R&D100 Award to SeizAlert in 2005 [1].