Semi-Rigid Artificial Tissue Sensitized by Encapsulated Cichorium Pumilum in Silica Nanoparticles for Photodynamic Therapy Application

摘要

In this study, synthesized Cichorium Pumilum (CP) encapsulated with Silica Nanoparticles (SiNPs) was prepared as an application for Photodynamic therapy. Semi-rigid artificial tissues with optical characteristics identical to that of humans were utilized as sample materials to establish the efficacy of CP encapsulated with SiNPs. The variations in the optical characteristics (transmittance,reflectance, scattering, absorption) of the tissue treated with encapsulated CP under light exposure (Intensity at 364nm ~0.36 mW/cm~2) were determined. Afterward, the optimal exposure times needed for naked CP and CP-SiNPs to engulf Red Blood Cells (RBCs) in the artificial tissue were also measured. Comparative analysis between the results of naked CP and encapsulated CP treatments of the artificial tissue showed the encapsulated CP has a 5 % higher efficacy than naked CP. The results confirmed the applicability of CP encapsulated with SiNP on artificial tissue and potential application on human tissue.