Development of CFTR activators from Chinese medicinal plants to improve pulmonary adaptation to altitude/hypoxia stress

摘要

@@ Introduction CFTR (Cystic Fibrosis Transmembrane Conductance Regulator) is a chloride channel on the airway epithelia, playing a major role in electrolyte and fluid transport. It is well documented that cystic fibrosis, the most common genetic respiratory disease, is caused by mutations in the CFTR gene that lead to dysfunction and/or improper localization of the protein. Approximately one in every 25 Caucasians carries one mutant version of this gene as a heterozygote.