The molecular epidemiology of classical swine fever viruses from Lao PDR and Asia: A brief review

摘要

Classical swine fever (CSF) is a highly contagious virus infection of swine caused by classical swine fever virus (CSFV), a member of the genus Pesti-virus, family Flaviviridae. The CSFV genome is a positive-sense single-stranded RNA molecule of approximately 12.3 kb. The open reading frame (ORF) encodes a single polyprotein that is post-translationally processed into structural and non-structural proteins. Flanking the ORF are non-coding regions at the 5' (5'NCR) and 3' (3'NCR) ends of approximately 360-385 and 228 bases, respectively. Molecular epidemiology techniques (also know as phylogenetic techniques) have been successfully applied to the investigation of CSF viruses to explain geographical and/or temporal relationships.