Cell-Biomaterial Interactions in Regenerative Medicine

摘要

Cell adhesion to extracellular matrices plays a central role in the formation, maintenance and repair of numerous tissues. Moreover, cell adhesion to adsorbed proteins or adhesive sequences engineered on surfaces is important to biomaterials, tissue engineering, and biotechnological applications. Cell adhesion to extracellular matrix proteins is primarily mediated by the integrin family of adhesion receptors. We have established biomolecular strategies for the engineering of bioartificial materials to direct integrin binding specificity and signaling.