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首页> 外文会议>International Conference of Recent Advances in Microwave Theoty and Applications >Synergistic role of Hydroxyapatite Nanoparticles and Pulsed Electromagnetic Field Therapy to prevent Bone loss in rats following exposed to Simulated Microgravity
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Synergistic role of Hydroxyapatite Nanoparticles and Pulsed Electromagnetic Field Therapy to prevent Bone loss in rats following exposed to Simulated Microgravity

机译：羟基磷灰石纳米颗粒和脉冲电磁场​​治疗的协同作用，以防止大鼠骨质损失暴露于模拟微匍匐

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The purpose of the present study was to use Capacitive Coupling of pulsed electromagnetic field (CC-PEMF) and Hydroxyapatite nanoparticles (HAp) as a countermeasure to prevent osteoporosis induced by simulated microgravity. We have used the hind limb-suspended (HLS) rat model to simulate microgravity induced bone losses for 45 days and in order to assess resulting Mineralogical (BMD, Ca and P), Biochemical (Osteocalcin, ALP and Type I Collagen) and Histological (SEM) changes and to study the effect of countermeasure (PEMF and HAp). Three-month-old, female wistar rats were randomly divided into controls (n =8), Hindlimb suspended (HLS) n =8), HLS with Pluse Electromagnetic Field (HLS+PEMF) n=8), HLS with Hydroxyapatite nanoparticles (HLS+HAp, n =8), and HLS with HAp and PEMF (HLS+PEMF+HAp, n=8). We observed: 1). a significant decrease (p<0.01) in BMD, Calcium, Phosphorus, Collagen I and ALP activity in Femur and Tibia in hind limb bone and serum osteocalcin in HLS rat as compared to ground control.2) Non-significant increase in BMD (P<0.1), Calcium (P<0.1), Phosphorus (P<0.5), Collagen I(P<0.1) and ALP activity (P<0.5) in Femur and Tibia in hind-limb bone and serum osteocalcin (P<0.5) in HLS+PEMF rats as compare to HLS. While 3). Significant increase in BMD (P<0.02), Calcium (P<0.05), Phosphorus (P<0.05), Collagen I (P<0.02), and ALP activity (p<0.02) in Femur and Tibia in hind-limb bone and non-significant increase in serum osteocalcin (P<0.1) in HLS+HAp rat as compared to HLS. 4). Highly significant increase in BMD (P<0.01), Calcium (P<0.01), Phosphorus (P<0.01), Collagen I (P<0.01) and ALP activity (P<0.01) in Femur and Tibia in hind-limb and serum osteocalcin (P<0.02). The present results suggest that a combination of low level pulsed electromagnetic field (CC-PEMF) and Silicon-substituted Hydroxyapatite nanoparticles (HAp) has potential to control bone loss induce due to simulated microgravity.
机译：本研究的目的是使用脉冲电磁场​​（CC-PEMF）和羟基磷灰石纳米颗粒（HAP）的电容耦合，以防止模拟微沉降诱导的骨质疏松症的对策。我们使用了后肢悬浮（HLS）大鼠模型来模拟显微抗痛诱导的骨质损失45天，以评估所产生的矿物学（BMD，CA和P），生化（骨钙素，ALP和I型胶原蛋白）和组织学（ SEM）改变并研究对策（PEMF和HAP）的影响。将三个月大的女性Wistar大鼠随机分为对照（n = 8），后肢悬浮（HLS）n = 8），HLS具有防绒电磁场（HLS + PEMF）n = 8），HLS与羟基磷灰石纳米颗粒（ HLS + HAP，N = 8），以及带有HAP和PEMF的HLS（HLS + PEMF + HAP，N = 8）。我们观察到：1）。与地面对照相比，BMD，股骨钙，磷，胶原蛋白和胫骨中的股骨和胫骨中的胫骨和胫骨中的血清骨蛋白的血清骨液中的显着减少（P <0.01）.2）BMD的非显着增加（P <0.1），钙（P <0.1），磷（P <0.5），胶原（P <0.1）和ALP活性（P <0.5）在后肢骨和血清骨钙素中的股骨和胫骨（P <0.5）在HLS + PEMF大鼠与HLS相比。而3）。 BMD（P <0.02），钙（P <0.05），磷（P <0.05），胶原蛋白I（P <0.02）和ALP活性（P <0.02）中的显着增加，在后肢骨骼中，胫骨和胫骨与HLS相比，HLS + HAP大鼠中血清骨钙素（P <0.1）的非显着增加。 4）。 BMD（P <0.01），钙（P <0.01），磷（P <0.01），股骨和胫骨中的胶原蛋白I（P <0.01），胶原蛋白I（P <0.01）（P <0.01）的高度显着增加，在后肢和血清中骨钙素（P <0.02）。本结果表明，低水平脉冲电磁场​​（CC-PEMF）和硅取代的羟基磷灰石纳米颗粒（HAP）的组合具有控制由于模拟的微匍匐剂导致的骨质损失诱导。

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