Multifunctional Magnetic Hydrogels with Polyethylene Glycol-Derivative Colloidal Nanospheres for Drug Delivery and Hyperthermia Applications

摘要

A novel magneto-active gel based nanomateiial system is presented to provide precise control of temperature to a localized area in response to externally controlled magnetic stimuli. Integration of ferromagnetic nanoparticles (Fe3O4) in the polyethylene glycol (PEG) based thermo-responsive polymer provides the swelling and de-swelling behavior of magnetic stimuli controlled system by generating the heat due to the hysteresis loss of Fe3O4 under exposure in an alternating magnetic field The shrinkage and heating capability of the nanomateiial system are investigated Magnetic nanopaiticle dependent shrinkage rate, actuation efficiency and temperature generation are ideal for various applications like magnetic particle/fluid based hyperthermia, magnetically controllable micro/nano pump drug delivery devices. Detail characterization of the magnetic hydrogel in terms of shrinkage and heating efficiency are in progress.