Biomonitoring of Perfluorochemicals Exposures in Newborn Infants from New York State using Blood Spots:1997 to 2004

摘要

Perfluorochemicals(PFCs)have been widely used as surfactants in industrial and commercial products for over 50 years.These chemicals are persistent in the environment,accumulated in human bodies,and can pose adverse health effects.In this study,we developed a novel method of using blood spots to monitor perfluorochemicals exposures in newborn infants,for the first time.Archived samples of blood spots from newborn infants from New York State Department of Health were analyzed for PFCs including PFOS,PFOA,PFOSA,PFNA,and PFHS using HPLC-EST-MS/MS.We found PFOS was the dominant compound in all blood spot samples followed by PFOA and PFOSA.Mean concentration of PFOS in newborn blood spots in 1997,2001,and 2004 were 4.60,4.42,and 2.08 ng/mL(wet wt),respectively.These values were 10 to 20 times lower than the concentrations reported for adult blood.The Concentrations of PFOSA were 2.37,1.06,and 0.29 ng/mL,and the concentrations of PFOA were 1.19,1.90,and 0.65 ng/mL,for 1997,2001,and 2004,respectively.Statistical difference in concentrations was found among years,but was less between summer and winter season within each year.The concentrations of PFOS in 1997 and in 2001 were similar but decreased significantly in 2004.The concentrations of PFOSA decreased significantly from 1997 to 2114;the temporal trend of PFOA was not clear.These findings indicated a positive effect of the phase-out of PFOS in 2000.