Surface Characterization of Poly(DL-lactide-CO-glycolide) (PLGA) Membranes Fabricated by the Various Methods for Biomedical Applications

摘要

A systematic study on molecular structure of Poly(DL-lactide-CO-glycolide) (PLGA) films by the methods of being chemically immobilized onto self-assembled monolayers (SAMs) and spin coating using Fourier transform infrared spectroscopy (FTIR), sum frequency generation (SFG) vibrational spectroscopy is reported. Especially, a surface sensitive second order nonlinear optical technique, SFG vibrational spectroscopy, was applied to study molecular structure on PLGA films. It is shown that the more chemical groups of PLGA thin films with being chemically immobilized have orientation than that of PLGA films made by spin coating on the basis of SFG vibrational spectroscopy data. The characterization of the other analytical techniques indicates similar results. This work will be an important step for future biomaterials design and understanding biosensors, biocompatibility and biomacromolecule (e.g. proteins and peptides) activity.