A Dynamic Modeling of Cellular Responding Continuous Ion Radiation (IR)

摘要

Genome stress can stimulate the cellular response in fighting against acute perturbations from outside, such as Ion Radiation (IR). To stimulate the investigating of the complicated regulating mechanisms of vital genes in fighting against continuous IR, a dynamic model of P53 gene regulatory network is proposed at single cell level. The model can be used to simulate the kinetics of the double-strand breaks (DSBs) generating and their repair, switch-like process of ataxia telangiectasia mutated (ATM) activation, as well as oscillating of the P53-MDM2 feedback loop in response to different IR dose domains. Especially, the model can predict the plausible outcomes of cellular response under some special circumstances, such as the abnormal transduction rates of mRNA.