Study on adsorption capability of novel oral activated carbon microsphere for endogenous glucose

摘要

Aim: Adsorption behaviors of activated carbon microsphere for glucose were investigated in order to study the possibility of using activated carbon microsphere to cure diabetes mellitus. Methods: We developed activated carbon microsphere and did its characteristic. The adsorption properties of activated carbon microsphere onto glucose in buffer solution were investigated. A systematic research was carried out to determine the optimal adsorption conditions, including different adsorption-time, dosage, pH and initial concentration. The adsorption of activated carbon microsphere onto a molecule of glucose was determined. The isotherm data of glucose was treated according to Langmuir and Freundlich isotherm equations. The goodness of fit of experimental data to these isotherm equations was tested and the parameters of equations were determined. Results: The BET specific surface of activated carbon microsphere was 1566m2/g, voidage was 0.653ml/g, and the volume of micropore was 0.478ml/g. Adsorption behaviors of the activated carbon microsphere for glucose were as follows: adsorption equilibrium was reached in 3 hours; there was no significant different effect in adsorption while pH was from 2 to 10, the adsorption equilibrium capacity increased with the increase of glucose concentration, the experimental data matched Langmuir isotherm equation. The deviation of equilibrium adsorption isotherms of glucose on activated carbon microsphere in binary components system and which in single system can be neglected. Conclusion: This adsorption process was composed by fast and slow diffusion, which belongs to the typical L type. It seems to demonstrate that the molecules are preferentially packed into micropores with monolayer adsorption in low concentration region. The adsorption would not be affected in the gastric or intestinal juice. It had no significantly influence for the adsorption behavior of ctivated carbon microsphere for glucose during the existence of creatinine in physiological concentration.