Preparation and Characterization of Intravenously Injectable Nimodipine Nanosuspension

摘要

The purpose of this study was to develop an alternative, improved and better tolerated formulation compared with commercial available nimodipine ethanol solution. In this study, nimodipine nanosuspension was prepared by high pressure homogenization (HPH). The effect of the production parameters such as pressure, cycle numbers and crushing principles on the mean particle size, 99% diameter and polydispersity of the nanosuspension was investigated. Characterization of the product was performed by scanning electron microscope (SEM) and differential scanning calorimeter (DSC). The safety of the nimodipine nanosuspension was discussed with special attention to contamination by microparticles and the increasing in saturation solubility Cs. Irritability study in rabbits showed that this formulation provided less local irritation and phlebitis than ethanol product, which represented a promising new drug formulation for intravenous therapy of subarachnoid hemorrhage (SAH)-related vasospasm.