Mechanism of Drug release from Pluronic F127-based in-situ hydrogel

摘要

Objective: To investigate the drug release mechanism from Pluronic F127 hydrogel. Method: Drug release from PF127 hydrogel was systematically studied by membrane-less model. The influence of PF127 concentration (20%, 25% and 30%) and the molecular weight of model drug (F-Na, FITC-rHV2 and FITC-BSA) were evaluated. The linear relationship between drug release and gel dissolution was discussed. Results: Both drug release and gel dissolution both followed zero-order kinetics. The release rate and gel dissolution rate both depended on the concentration of PF 127. Good linear relationship was observed between drug release and gel dissolution Conclusion: The release of drug from Pluronic F127 in-situ hydrogel was controlled by the dissolution of gel.