Genetically engineered viruses (vectors) provide an efficient system for gene delivery and expression of medically-relevant proteins. GenVec's platform technology uses replication-deficient Adenoviral vectors (Adenovectors) for both therapeutic and vaccine applications. The "GV11" Adenovector, which has complete deletions of both the El and E4 domains and partial deletion of the E3 domain is, by design, incapable of replicating in normal human cells. Replacement of the Adenovirus El domain with a protein expression cassette enables safe delivery and expression of proteins of interest. This concept is presented in Figure 1.
展开▼
