Investigation of tissue oxygenation by in vivo laser-inducedphotodissociation of cutaneous arterial blood oxyhemoglobin

摘要

A novel method of direct control of local tissue oxygenation based on laser-induced photodissociation of oxyhemoglobinin cutaneous blood vessels is discussed. New technology in selective and local increase of the concentration of freemolecular oxygen in tissue that enhances metabolism of cells is demonstrated. Direct in vivo measurements of the tissueoxygen tension are carried out on human skin. Kinetics of oxygen tension in tissue is investigated under the effect of He-Ne laser radiation at the power of 1mW relatively to initial value of tissue oxygen tension. The results of experimentalstudy the kinetics of oxygen distribution into tissue from arterial blood is presented. Biomedical applications of proposednew technology in laser therapy of pathologies where elimination of local tissue hypoxia is critical are discussed.