We present arguments suggesting that large size overlapping instantons isthe driving mechanism of the confinement-deconfinement phase transition at nonzero chemical potential mu. The arguments are based on the picture that instantons at very large chemical potential in the weak coupling regime are localized configurations with small sizes rho approx (mu)~(-1). At the same time, the same instantons at smaller chemical potential in the strong coupling regime are well represented by the so-called instanton-quarks with fractional topological charge 1/N_(c). We estimate the critical chemical potential (mu)_(c)(T) where transition between these two regimes takes place. We identify this transition with confinement- deconfinement phase transition.
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