Laser spectroscopy as a method for diagnosing Cancer and assessing the efficacy of treatment of malignant neoplasms

摘要

The issues of early diagnosis and effective treatment of malignant neoplasms are of vital importance for the Urals region which in 1950-1960 became the site of several radiation incidents with the resultant overexposures of dozens of thousands of residents who have manifested increased risks of leukemia and solid cancer incidence. The present study has demonstrated the efficacy of the method of laser-correlation spectrometry (LCS) of blood plasma and serum for early diagnosis of malignant neoplasms and prediction of relapses of tumor following radical treatment. The LCS method is characterized by a sufficiently high diagnostic sensitivity in relation to malignant tumors. It has been established that LC spectra obtained for patients with malignant neoplasms differ significantly from those for patients with non-cancer pathology of the same sites. The LCS methodology has manifested a sufficiently high prognostic sensitivity (76.6%) in relation to complete regression after radical treatment and progression (78.0%) of the tumor process. A positive prognostic criterion of the course of a malignant neoplasm after radical treatment in patients without relapse and metastases is a statistically significant (p < 0.01) reduction in the number of particles with a small hydrodynamic radius in blood plasma and serum to normal values (data from 1-year clinical observations). In patients with signs of a progressing cancerous process after radical treatment a comparison of summarized LC spectra of blood plasma and serum determined before and after radical treatment showed no significant differences.