General discussion II

摘要

Ono: Our general discussion will revolve around the last three papers. Dr Kawakami, I really liked the IgE painting on the skin you showed. Was this with highly cytokinergic (HC) or poorly cytokinergic (PC) IgE? Kawakami: We tested both. Ono: Is there any strain specificity in the tripling of mast ceE numbers that you saw in the response that one antibody was able to promote? If you do the same experiment with HC and PC in many different strains of mice, what happens? Kawakami: We tried a couple of strains. Only NC/Nga mice worked for this experiment. These are mice that are being used as an atopic dermatitis model. Galli: Do you think it is because there is an abnormality of the barrier function of the epidermis in the NC/Nga mouse? IgE is a large protein to get through the epidermis.