The susceptibility of bacteria to photodynamic inactivation with lanthanide complexes of chlorin e6

摘要

Photodynamic inactivation (PDI) may be a very promising alternative method for antimicrobial treatment of many localised infections. In the present study we report the activity of three lanthanides (Eu(III), Pr(III), Yb(III)) complexes of Fotolon sensitizer, composed of chlorin e6 and polyvinylpyrrolidone (PVP), against standard E.coli P. aeruginosa, K. pneumoniae and S. aureus ATCC strains. The 160±10mW/cm~2 of 651 nm laser light was applied for 600 seconds after photosensitiser administration (50μg/ml) and 30 minutes incubation time. Impact of pure Fotolon and pure lanthanides solution was examined as control groups.