Colloidal β-TCP Facilitates Synthesis of Collagen Nano-composite

摘要

Preparing collagen composites is recognized as difficult because it has been believed that composites cannot be synthesized without complicated processing. However, we found that the alkaline colloidal β-TCP facilitates synthesis of collagen composites. Many collagen molecules were tightly polymerized to form stable collagen fiber in a β-TCP/collagen composite by catalysis of the -P-O-P-polyphosphate chain generated. Cross-linking between collagen NH~+ amino groups and -P-O-P-, and an increase of bonding strength between Ca~(++) and RCOO~- of the collagen molecules were identified in the composite. These chemical reactions due to the colloidal β-TCP might be crucial in the synthesis of collagen composites.