Dimensioning of a new micro-needle for the dispense of drugs in tumors and cell clusters

摘要

In medical treatment, there is a constant need to deliver active molecules into targeted cells, but this dispense is often difficult and time consuming. In order to improve the rapidity of dispense and its efficiency, a special injection needle has been designed. This micro-needle has a central channel and presents side exits uniformly distributed on the sides. The advantages of this type of needle is that drug delivery starts from all side exits disposed along the needle tip. For the best possible efficiency of the micro-needle, all side exits should have the same flow rate. Eventually, the needle may be used as an electrode to increase the uptake rate. An inverse algorithm for the dimensioning of such a needle has been set up; this algorithm is based on a lumped model approach. We verify that it is numerically consistent with SABER direct calculation. Moreover the approach has been proved to be correct after micro-fabrication of such needles and verification that drug delivery requirements are met.